Nomenclature used for steroidogenic enzymes

Gene symbol	Prior designation	Functional name
CYP11A1	P450scc	Cholesterol side-chain cleavage enzyme and desmolase in all zones
HSD3B2	3-beta-hydroxysteroid dehydrogenase	3-beta-hydroxysteroid dehydrogenase in the ZG and ZF
CYP17	P450c17	17-alpha-hydroxylase activity in the ZF 17-alpha-hydroxylase and 17,20-lyase activity in the ZR
CYP21A2	P450c21	21-hydroxylase in the ZF and ZG
CYP11B1	P450c11	11-beta-hydroxylase in the ZF
CYP11B2	P450c11as	Aldosterone synthase and corticosterone methyl oxidase in the ZG

ZG: zona glomerulosa; ZF: zona fasciculata; ZR: zona reticularis.

Graphic 55287 Version 3.0

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