Bullous drug eruptions

Drug eruption	Clinical features	Common medications
Linear IgA bullous dermatosis	Annular erythema and blisters ("crown of jewels").	Vancomycin, penicillin, cephalosporins, ACE inhibitors, NSAIDs
Pseudoporphyria	Photodistributed blisters on dorsal hands, forearms, face. Similar clinical presentation as porphyria cutanea tarda (with negative porphyrin studies).	NSAIDs, tetracyclines, furosemide
Fixed drug eruption	Dusky, violaceous patch. Hemorrhagic vesicle or bulla. History of recurrences at same location with medication usage.	Sulfonamides, NSAIDs, tetracyclines
Stevens-Johnson syndrome, toxic epidermal necrolysis	Widespread, dusky erythema with epidermal detachment and flaccid blisters. Prominent mucosal involvement.	Antibiotics, antiseizure medications, allopurinol, dapsone, NSAIDs

IgA: immunoglobulin A; ACE: angiotensin-converting enzyme; NSAID: nonsteroidal anti-inflammatory drug.

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