Stroke in a three-day-old term newborn with left-sided clonic seizures

(A) Head CT on day of life 3 shows focal hypodensity (arrows) consistent with right MCA territory arterial ischemic stroke. Brain MRI confirms acute infarction (arrows) on axial diffusion-weighted sequences (B) and T2-weighted sequences (C). On diffusion-weighted sequences (B), subtle diffusion restriction (asterisk and dashed lines) in ipsilateral internal capsule, corpus callosum and thalamus depict foci of probable Wallerian or trans-synaptic degeneration.