Conventional cerebral MRI imaging in adult-onset vanishing white matter disease

Sagittal T2-weighted (A) and axial fluid-attenuated inversion recovery (FLAIR) (B) are shown. Virtually, all hemispheric white matter appeared homogeneously hyperintense on T2-weighted and hypointense on T1-weighted (not shown) with atrophy of the corpus callosum. On FLAIR, large part of the white matter has a signal identical to CSF, surrounded by a rim of hyperintensity demonstrating the cavitated breakdown of the white matter.