Pathogenesis of myelofibrosis

Schematic representation of the currently held opinion on the factors contributing to the pathogenesis of bone marrow fibrosis in myeloid metaplasia.

TGF-β: transforming growth factor; PDGF: platelet derived growth factor; EGF: epidermal growth factor; bFGF: basic fibroblast growth factor.

Graphic 56172 Version 1.0

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