Version May 2024
| Non-severe infection | |
| Isolated cutaneous infection | TMP-SMX 5 to 10 mg/kg orally of the trimethoprim component per day in two divided doses (first-line regimen) |
| OR | |
| Minocycline 100 mg orally twice daily (alternative regimen) | |
| Non-severe mycetoma | TMP-SMX 10 mg/kg orally of the trimethoprim component per day in two divided doses +/- |
| Dapsone 100 mg orally once daily | |
| Mild or moderate pulmonary disease in immunocompetent hosts | TMP-SMX 5 to 10 mg/kg orally of the trimethoprim component per day in two divided doses |
| Mild or moderate pulmonary disease in immunocompromised hosts | TMP-SMX 15 mg/kg orally of the trimethoprim component per day in three or four divided doses |
| Severe infection | |
| Severe mycetoma | Imipenem 500 mg IV every 6 hours +/- |
| Amikacin 7.5 mg/kg IV every 12 hours | |
| Severe pulmonary or disseminated disease (without CNS involvement) | TMP-SMX 15 mg/kg IV of the trimethoprim component per day in three or four divided doses PLUS |
| Amikacin 7.5 mg/kg IV every 12 hours (first-line regimen) | |
| OR | |
| Imipenem 500 mg IV every 6 hours PLUS | |
| Amikacin 7.5 mg/kg IV every 12 hours (alternative regimen) | |
| Involvement of ≥2 sites in immunocompromised hosts (without CNS involvement) | TMP-SMX 15 mg/kg IV of the trimethoprim component per day in three or four divided doses PLUS |
| Amikacin 7.5 mg/kg IV every 12 hours (first-line regimen) | |
| OR | |
| Imipenem 500 mg IV every 6 hours PLUS | |
| Amikacin 7.5 mg/kg IV every 12 hours (alternative regimen) | |
| Isolated CNS disease | TMP-SMX 15 mg/kg IV of the trimethoprim component per day in three or four divided doses PLUS |
| Imipenem 500 mg IV every 6 hours | |
| CNS disease with multiorgan involvement (ie, at least one other site) | TMP-SMX 15 mg/kg IV of the trimethoprim component per day in three or four divided doses PLUS |
| Imipenem 500 mg IV every 6 hours PLUS | |
| Amikacin 7.5 mg/kg IV every 12 hours | |
| Life-threatening disease | TMP-SMX 15 mg/kg IV of the trimethoprim component per day in three or four divided doses PLUS |
| Imipenem 500 mg IV every 6 hours PLUS | |
| Amikacin 7.5 mg/kg IV every 12 hours | |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
