Version July 2025
| Affected system | Diagnosis | Manifestation |
| Dermatologic | SLE | Malar rash and hair loss |
| Dermatomyositis | Gottron's papules | |
| Systemic JIA | Evanescent, pink macular rash | |
| IgAV (HSP) | Lower-extremity purpuric lesions | |
| Parvovirus | "Slapped cheek" erythema | |
| ARF | Erythema marginatum | |
| Kawasaki disease | Ranging from nonspecific erythema to subcutaneous edema and skin peeling | |
| Ophthalmologic | Oligoarthritis or psoriatic JIA | Asymptomatic chronic anterior uveitis |
| Enthesitis related arthritis | Acute symptomatic uveitis (pain, redness) | |
| Kawasaki disease | Conjunctival injection without discharge | |
| Sjögren's syndrome | Dry eyes with keratitis | |
| Oral | SLE | Painless oral ulcers on palate |
| Behçet disease | Large, extremely painful oral ulcers | |
| Kawasaki disease | Mucositis and strawberry tongue | |
| Respiratory | CF or immunodeficiency | Recurrent pneumonia |
| Granulomatosis with polyangiitis | Destructive upper tract lesions | |
| SLE or systemic JIA | Pleuritis | |
| SLE or scleroderma | Interstitial lung disease | |
| Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) | Eosinophilic pneumonia | |
| Cardiovascular | ARF or endocarditis | New heart murmur |
| SLE, systemic JIA, or ARF | Pericarditis | |
| SLE or scleroderma | Raynaud phenomenon | |
| Takayasu arteritis | Absent pulses | |
| Kawasaki disease | Carditis, coronary artery aneurysms | |
| Gastrointestinal | IBD, SLE, vasculitis, leukemia, lymphoma, or other malignancy | Weight loss or poor growth |
| IBD | Diarrhea and abdominal pain | |
| Reactive arthritis | Preceding infectious gastroenteritis | |
| IgAV (HSP) | Intermittent colicky abdominal pain | |
| Periodic fevers (FMF, PFAPA) | Abdominal pain during fever episodes | |
| Genitourinary | Gonococcal arthritis | Pustular urethritis or cervicitis |
| Reactive arthritis | Nongonococcal urethritis | |
| Behçet disease or IBD | Large, painful genital ulcerations | |
| Hematologic | SLE or hemoglobinopathy (eg, SCD) | Pancytopenia, hemolytic anemia |
| Leukemia, lymphoma | Cytopenias, blasts on smear | |
| Bleeding disorders | Hemarthrosis | |
| Neurologic | SLE | Seizures and psychosis |
| SLE or fibromyalgia | Difficulty concentrating | |
| SLE, vasculitis, or hypercoagulability | Stroke | |
| Vasculitis, including Kawasaki disease | Asymmetric polyneuropathy, severe irritability | |
| Dermatomyositis and polymyositis | Proximal muscle weakness |
