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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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The effect of selecting different risk cut-offs for Down syndrome screening

The effect of selecting different risk cut-offs for Down syndrome screening
Down syndrome screening test Term risk cut-off* Detection rate (%) False-positive rate (%) Positive predictive value (%)
Quadruple 1:350 88 7.7 2.5 (1:39)
CombinedΔ 86 6.4 3 (1:33)
IntegratedΔ 92 3.9 5 (1:19)
Quadruple 1:300 86 6.6 3 (1:34)
CombinedΔ 84 5.5 3 (1:29)
IntegratedΔ 91 3.4 6 (1:17)
Quadruple 1:250 84 5.7 3 (1:30)
CombinedΔ 83 4.7 4 (1:25)
IntegratedΔ 90 3.0 7 (1:14)
Quadruple 1:200 82 4.7 4 (1:25)
CombinedΔ 81 3.8 5 (1:21)
IntegratedΔ 89 2.4 8 (1:12)
Quadruple 1:150 79 3.6 5 (1:20)
CombinedΔ 78 2.8 6 (1:16)
IntegratedΔ 87 1.9 9 (1:10)
Quadruple 1:100 74 2.5 7 (1:15)
CombinedΔ 75 1.9 8 (1:11)
IntegratedΔ 85 1.3 12 (1:7)
Source of estimates are from the parameters/tables from the SURUSS study and a birth prevalence of Down syndrome of 1:450. Quadruple refers to second-trimester AFP, uE3, total/intact hCG (or the free beta subunit), and inhibin A. Combined refers to first-trimester NT, PAPP-A, and total/intact hCG (or the free beta subunit). Integrated refers to first-trimester NT, PAPP-A, and second-trimester Quadruple test.
AFP: alpha-fetoprotein; uE3: unconjugated estriol; hCG: human chorionic gonadotropin; NT: nuchal translucency; PAPP-A: pregnancy-associated plasma protein A.
* The approximate age cut-off equivalent for 1:350, 1:250, 1:200, 1:150, and 1:100 are 35, 36, 37, 38, and 39 years of age, respectively (eg, 1:350 is approximately the same as the age-associated risk of a group of women delivering at age 35).
¶ The positive predictive value as a percentage and the associated odds in parentheses.
Δ First-trimester sample obtained at 12 weeks of gestation. Performance will differ slightly at other weeks of gestation between 9 and 13.
Data from: Wald NJ, Rodeck C, Hackshaw AK, et al. First and second trimester antenatal screening for Down's syndrome: The results of the Serum, Urine, and Ultrasound Screening Study (SURUSS). Health Technol Assess 2003; 7:1.
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