Reactivity of paraneoplastic antineuronal antibodies

Reactivity of different paraneoplastic antibodies with the nervous system.

(A) Reactivity of anti-Hu antibodies with human cerebral cortex. There is predominant staining of the nuclei of the neurons (with sparing of the nucleoli) and milder staining of the cytoplasm. Glial cells are not immunoreactive.

(B) Reactivity of anti-Yo antibodies with rat cerebellum. There is intense immunolabeling of the cytoplasm of the Purkinje cells and of neurons of the molecular layer.

(C) Reactivity of anti-Tr antibodies with rat cerebellum. There is a characteristic dot-like immunolabeling of the cytoplasm of Purkinje cells and the neuropil of the molecular layer of cerebellum.