Major causes of chronic fatigue

Psychologic

Depression

Anxiety

Somatization disorder

Malnutrition or drug addiction

Pharmacologic

Hypnotics

Antihypertensives

Antidepressants

Drug abuse and drug withdrawal

Endocrine-metabolic

Hypothyroidism

Diabetes mellitus

Apathetic hyperthyroidism

Pituitary insufficiency

Hypercalcemia

Adrenal insufficiency

Chronic renal failure

Hepatic failure

Neoplastic-hematologic

Occult malignancy

Severe anemia

Infectious

Endocarditis

Tuberculosis

Mononucleosis

Hepatitis

Parasitic disease

HIV infection

Cytomegalovirus

Cardiopulmonary

Chronic heart failure

Chronic obstructive pulmonary disease

Connective tissue disease

Rheumatoid disease

Disturbed sleep

Sleep apnea

Esophageal reflux

Allergic rhinitis

Psychologic causes (see above)

Idiopathic (diagnosis by exclusion)

Idiopathic chronic fatigue

Chronic fatigue syndrome

Fibromyalgia

Differential_of_chronic_fat.htm

Adapted from: Gorroll, AH, May, LA, Mulley, AG Jr (Eds), Primary Care Medicine: Office Evaluation and Management of the Adult Patient, 3rd ed, JB Lippincott, Philadelphia, 1995.

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Major causes of chronic fatigue