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Normal values for combined impedance-pH monitoring based on 95th percentile data in healthy volunteers off and on acid-suppressive therapy

Normal values for combined impedance-pH monitoring based on 95th percentile data in healthy volunteers off and on acid-suppressive therapy
 

Off therapy

(N = 60)

On therapy (PPI twice daily)

(N = 20)

Esophageal pH data
Percent time pH <4 Total 6.7% 1.3%
Upright 9.7% 2.2%
Recumbent 2.1% 0.0%
Esophageal MII-data
Nr. reflux episodes Total 73 48
Acid 55 12
Non-acid 27 44
PPI: proton pump inhibitor; MII: multichannel intraluminal impedance.
Data from:
1. Shay, S, Tutuian, R, Sifrim, D, et al. Twenty-Four Hour Ambulatory Simultaneous Impedance and pH Monitoring: A Multicenter Report of Normal Values From 60 Healthy Volunteers. Am J Gastroenterol 2004; 99:1037.
2. Tutuian, R, Mainie, I, Agrawal, A, et al. Normal values for ambulatory 24-h combined impedance-pH monitoring on acid suppressive therapy. Gastroenterology 2006; 130 Suppl 2:A171.
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