Examples of drugs and biologics that can cause interstitial lung disease

Antibiotics

Ethambutol

Minocycline

Nitrofurantoin, acute and chronic

Anti-inflammatory agents

Abatacept

Azathioprine*

Cyclophosphamide*

Gold

Interleukin-1 blockers (anakinra)

Leflunomide

Methotrexate*

Nonsteroidal antiinflammatory agents

Penicillamine

Rituximab (anti-CD20 monoclonal antibody)

Sulfasalazine

Thalidomide*

Tocilizumab

Tumor-necrosis factor-alpha blockers

Anti-arrhythmic agents

Amiodarone

Tocainide

Antineoplastic agents

Alkylating agents

Busulfan

Chlorambucil

Cyclophosphamide*

Melphalan

Procarbazine

Antibiotics

Bleomycin sulfate

Mitomycin C

Antimetabolites

Azathioprine*

Cytosine arabinoside

Methotrexate*

Nitrosoureas

BCNU (carmustine)

CCNU (lomustine)

Methyl-CCNU (semustine)

Other

Alpha interferon

Docetaxel

Etoposide (VP-16)

Gefitinib

Nilutamide

Paclitaxel

Temsirolimus

Thalidomide*

Drug-induced systemic lupus erythematosus

Hydantoins

Hydralazine

Isoniazid

Penicillamine

Procainamide

Illicit drugs

Cocaine

Heroin

Methadone

Propoxyphene

Talc

Miscellaneous

Bacille Calmette-Guerin (BCG)

Bromocriptine

Drugs inducing pulmonary infiltrates and eosinophilia

L-tryptophan

Oxygen

Radiation

Statins

* Drugs that are used as both antineoplastic and anti-inflammatory agents.

Adapted from: Camus P. Interstitial lung disease from drugs, biologics, and radiation. In: Interstitial Lung Disease, 5th ed, Schwarz MI, King TE Jr (Eds), People's Medical Publishing House, Shelton, 2011.

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Examples of drugs and biologics that can cause interstitial lung disease