Variable serum insulin concentrations with pre-mixed insulins

24-hour serum insulin profiles after the injection of two pre-mixed insulin preparations: one containing a total of 0.3 units/kg of NPH and regular insulin in a 50/50 ratio (dashed line), and one containing the same total amount of NPH and regular insulin in a 70/30 ratio (solid line). Serum insulin concentrations were significantly higher during the first six hours with the 50/50 regimen, which contained more regular insulin. To convert serum insulin values to microU/mL, divide by 6.