Differential diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)

	NLPHL	LRCHL	T/HRBCL
Clinical presentation	53 percent Stage I	46 percent Stage I	8 percent Stage I
	28 percent Stage II	24 percent Stage II	8 percent Stage II
	14 percent Stage III	24 percent Stage III	15 percent Stage III
	6 percent Stage IV	6 percent Stage IV	69 percent Stage IV
	10 percent B symptoms	10 percent B symptoms	54 percent B symptoms
Neoplastic cells	L&H cell	Reed-Sternberg cell which can resemble L&H cells or lacunar cells	Can resemble the L&H cell, centroblast, immunoblast, or Reed-Sternberg cell
Background cells	B cells >T cells small B cells, CD3+CD4+CD57+ T cells and follicular dendritic cells	Variable. In nodular cases, Reed-Sternberg cells may be found adjacent to B cell follicles	T cells >B cells CD8+ cytotoxic T cells and histiocytes
Growth pattern	Nodular, at least in part	Usually nodular but can be diffuse	Usually diffuse
Tumor cell immunophenotype
CD15	-	+	-
CD30	-/+	+/-	-/+
CD20	+	-/+	+
CD45	+	-	+
EMA	+/-	-	+/-
BOB-1	+	-/+	+
OCT-2	+	-/+	+
BLC6	+	-/+	+/-

Differential_dx_NLPHL.htm

NLPHL: Nodular lymphocyte-predominant Hodgkin lymphoma; LRCHL: Lymphocyte-rich classical Hodgkin lymphoma; T/HRBCL: T-cell/histiocyte-rich B-cell lymphoma.
+: all cases positive.
+/-: majority of cases positive.
-/+: minority of cases positive.
-: all cases negative.

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خرید پکیج

Differential diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)