Version June 2024
| Immune deficit | Common causes | Organisms |
| Neutrophil disorders | ||
| Neutropenia | Chemotherapy Leukemia AIDS Felty syndrome Viral infections | Gram-negative bacilli (enteric and nonenteric) Staphylococcus aureus Coagulase-negative Staphylococcus Streptococci Fungi (Aspergillus spp, Candida spp) |
| Neutrophil chemotaxis | Diabetes mellitus Cirrhosis, alcoholism Uremia Hodgkin's disease Trauma, burns Lazy leukocyte syndrome | S. aureus Candida spp Streptococci Mucorales |
| Neutrophil killing | Chronic granulomatous disease Myeloperoxidase deficiency | S. aureus Escherichia coli Fungi (Aspergillus spp, Candida spp) |
| T lymphocyte deficiency | HIV/AIDS Lymphoma Chemotherapy Transplantation Glucocorticoids Viral infection T cell-depleting antibodies | Viruses (latent herpesviruses, papillomaviruses, respiratory viruses) Intracellular bacteria (Legionella spp, mycobacteria) Nocardia spp Fungi (Pneumocystis jirovecii, Cryptococcus spp, Histoplasma capsulatum) Parasites (Strongyloides spp, Toxoplasma spp) |
| B lymphocyte deficiency | Multiple myeloma Acute leukemia Burns Congenital Drugs (anti-B-cell therapies, azathioprine, mycophenylate) Enteropathies Plasmapheresis Glucocorticoids | Encapsulated bacteria (Pneumococcus, Haemophilus influenzae, Neisseria meningitides) Salmonella spp Campylobacter Giardia |
| Spleen | Splenectomy Sickle cell disease Cirrhosis | Encapsulated bacteria (Pneumococcus, H. influenzae, N. meningitidis) Capnocytophaga |
| Complement | Congenital/acquired deficiencies | S. aureus Encapsulated bacteria (Pneumococcus, H. influenzae, N. meningitidis) |
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