Recommendations from the United States Preventive Services Task Force on who should be offered genetic testing for BRCA mutations*^[1]

For non-Ashkenazi Jewish women:

2 first-degree relatives with breast cancer, 1 of whom was diagnosed at age 50 or younger

A combination of 3 or more first- or second-degree relatives with breast cancer regardless of age at diagnosis

A combination of both breast and ovarian cancer among first- and second-degree relatives

A first-degree relative with bilateral breast cancer

A combination of 2 or more first- or second-degree relatives with ovarian cancer, regardless of age at diagnosis

A first- or second-degree relative with both breast and ovarian cancer at any age

History of breast cancer in a male relative

For women of Ashkenazi Jewish descent:

Any first-degree relative (or 2 second-degree relatives on the same side of the family) with breast or ovarian cancer

* These recommendations do not apply to women with a family history of breast or ovarian cancer that includes a relative with a known deleterious BRCA mutation.

Reference:

U.S. Preventive Services Task Force. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility: recommendation statement. Ann Intern Med 2005; 143:355.

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خرید پکیج

​Recommendations from the United States Preventive Services Task Force on who should be offered genetic testing for BRCA mutations*[1]

Recommendations from the United States Preventive Services Task Force on who should be offered genetic testing for BRCA mutations*^[1]