Atypical features of juvenile idiopathic arthritis that should prompt consideration of leukemia*

Nocturnal pain that may cause waking

Severe pain, requiring opiate analgesia

Pain out of proportion to severity of arthritis

Systemic symptoms out of proportion to severity of arthritis

Nonarticular bone pain

Atypical_features_JIA.htm

* Particularly before the initiation of corticosteroid or cytotoxic therapy.

Adapted from Murray, MJ, Tang, T, Ryder, C, et al. BMJ 2004; 329:959.

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