Laboratory findings during the evolution of iron deficiency anemia

Test	Storage iron deficiency	Iron-limited erythropoiesis	Iron-deficiency anemia
Hemoglobin	Normal	Normal	Decreased
Transferrin saturation*	Normal	Decreased	Decreased
Erythrocyte protoporphyrin	Normal	Increased	Increased
Plasma ferritin^¶	Decreased	Decreased	Decreased
Reticulocyte hemoglobin content (CHr) or equivalent (Ret-He)	Normal	Decreased	Decreased

* Transferrin saturation is calculated as the serum iron/total iron binding capacity (SI/TIBC).
¶ Ferritin is an acute phase reactant, and serum levels are increased by liver disease, inflammation, and malignancy. In these settings, it is not a good reflection of iron stores.

Graphic 57739 Version 5.0

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