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Prognostic stratifications for advanced hepatocellular carcinoma

Prognostic stratifications for advanced hepatocellular carcinoma
Multivariate Cox model and the points assigned to each category of prognostic factors in the new prognostic score system
Characteristics Point
Patient characteristics
Ascites Yes 2
No 0
Abdominal pain Yes 2
No 0
Weight loss Yes 2
No 0
Child-Pugh grade C 5
B 2
A 0
Biochemistry
Serum alkaline phosphatase (ALP), int. unit/L >200 3
≤200 0
Total bilirubin >50 int. unit/L (2.9 mg/dL) 3
>33 to ≤50 int. unit/L (1.9 mg/dL to 2.9 mg/dL) 1
≤33 int unit/L (1.9 mg/dL) 0
Urea >8.9 mmol/L (>25 mg/dL) 2
≤8.9 mmol/L (≤25 mg/dL) 0
Tumor characteristics
Portal vein thrombosis Yes 3
No 0
Tumor size Diffuse 4
>5 cm 3
≤5 cm 0
Lung metastases Yes 3
No 0
Serum alpha-fetoprotein (AFP), ng/mL >400 4
≤400 0
Probability of patients surviving at least 3 months estimated by the advanced liver cancer prognostic system score
Prognosis Score 3-month survival rate, %
Good 0 to 2 >81
3 to 6 72 to 80
7 to 8 66 to 69
Intermediate 9 63
10 to 12 51 to 59
13 to14 42 to 7
15 38
Poor 16 33
17 to 19 21 to 29
20 to 22 10 to 17
≥23 <10
int. unit: international unit.
Reproduced with permission from: Yau T, Yao TJ, Chan P, et al. A new prognostic score system in patients with advanced hepatocellular carcinoma not amendable to locoregional therapy: implication for patient selection in systemic therapy trials. Cancer 2008; 113:2742. Copyright © 2008 John Wiley & Sons, Inc.
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