Glucagon: Posttranslational processing

Schematic representation of glucagon posttranslational processing that occurs in the pancreas and small intestine. The gene transcript is translated into a preprohormone capable of producing glucagon, glucagon-like peptide (GLP)-1, and GLP-2. Only glucagon is produced in the pancreas by tissue-specific processing. In the small intestine, GLP-1 and GLP-2 are the primary products.