NCI CTCAE v5.0 heart failure

Adverse event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Heart failure	Asymptomatic with laboratory (eg, BNP [B-Natriuretic Peptide]) or cardiac imaging abnormalities	Symptoms with moderate activity or exertion	Symptoms at rest or with minimal activity or exertion; hospitalization; new onset of symptoms	Life-threatening consequences; urgent intervention indicated (eg, continuous intravenous therapy or mechanical hemodynamic support)	Death

Heart failure is characterized by the inability of the heart to pump blood at an adequate volume to meet tissue metabolic requirements, or, the ability to do so only at an elevation in the filling pressure. For left-sided heart failure, refer to the table on left ventricular systolic dysfunction; tables on restrictive cardiomyopathy and decreased ejection fraction may also be appropriate.

NCI CTCAE: National Cancer Institute Common Terminology Criteria for Adverse Events.

Reproduced from: Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0, November 2017, National Institutes of Health, National Cancer Institute. Available at: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf (Accessed March 27, 2018).

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NCI CTCAE v5.0 heart failure