Version July 2025
| Drug | Glomerular filtration rate (GFR) mL/min* | Removal by dialysis | |||
| >50 (normal renal function) | 10-50 | <10 | |||
| Cefazolin | 1 to 2 g every 8 hours | 0.5 to 1 g every 12 hours | 0.5 to 1 g every 24 hours | Yes (HD), No (PD) | |
| Cefuroxime | 0.75 to 1.5 g every 6 to 8 hours | 0.75 to 1.5 g every 8 to 12 hours | 0.75 g every 24 hours | Yes (HD, PD) | |
| Cefoxitin | 1 to 2 g every 4 to 6 hours | 1 to 2 g every 8 to 12 hours | 0.5 to 1 g every 24 hours | Yes (HD), No (PD) | |
| Cefotetan | 1 to 2 g every 12 hours | 1 to 2 g every 24 hours | 1 to 2 g every 48 hours | Yes (HD) | |
| Cefotaxime | 1 to 2 g every 6 hours | 1 to 2 g every 8 to 12 hours | 1 to 2 g every 12 to 24 hours | Yes (HD), No (PD) | |
| Ceftriaxone | 1 to 2 g every 12 to 24 hours | NC | NC | No (HD) | |
| Ceftazidime | 1 to 2 g every 8 hours | 1 to 2 g every 12 to 24 hours | 0.5 to 1 g every 24 to 48 hours | Yes (HD, PD) | |
| Cefepime | 1 to 2 g every 8 to 12 hours | 0.5 to 2 g every 12 to 24 hours | 0.25 to 1 g every 24 hours | Yes (HD) | |
| Ceftaroline¶ | 600 mg every 12 hours | 300 to 400 mg every 12 hours | 200 to 400 mg every 12 hours | Yes (HD) | |
| CefiderocolΔ | 2 g every 8 hours (for CrCl ≥60 mL/min) | 1.5 g every 8 hours (for CrCl 30 to 59 mL/min) | 1 g every 8 hours (for CrCl 15 to 29 mL/min) | 0.75 g every 12 hours (for CrCl <15 mL/min) | Yes (HD) |
HD: hemodialysis; NC: no change; PD: peritoneal dialysis.
* Usual adult dosing and renal adjustments shown are for moderate to severe infections. For specific dosing recommendations, refer to related disease treatment topics and drug information included with UpToDate.
¶ Infused over 1 hour.
Δ Infused over 3 hours.