Schematic representation of the proposed structure of the calcium receptor cloned from bovine parathyroid tissue

The structure of the human receptor is very similar.

SP: signal peptide; HS: hydrophobic substance; PKC: protein kinase C.

Adapted with permission from: Brown EM, Gamba G, Riccardi D, et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature 1993; 366:575.

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Schematic representation of the proposed structure of the calcium receptor cloned from bovine parathyroid tissue