Version June 2024
| Intensive phase | Continuation phase | ||
| Drugs | Interval and doses¶ minimal duration | Drugs | Interval and doses¶Δ minimal duration |
| Regimen 1: Preferred regimen for HIV-infected adults with newly diagnosed tuberculosis | |||
| INH | Daily for 8 weeks 7 days per week for 56 doses (8 weeks), or 5 days per week for 40 doses (8 weeks)◊ | INH/RIF | 7 days per week for 126 doses (18 weeks), or 5 days per week for 90 doses (18 weeks)◊ |
| RIF | |||
| PZA | |||
| EMB | |||
| Regimen 2: Alternative regimen for HIV-infected adults in setting of resistance or intolerance to PZA | |||
| INH | Daily for 8 weeks 7 days per week for 56 doses (8 weeks), or 5 days per week for 40 doses (8 weeks)◊ | INH/RIF | 7 days per week for 217 doses (31 weeks), or 5 days per week for 155 doses (31 weeks)◊ |
| RIF | |||
| EMB | |||
DOT: directly observed therapy; EMB: ethambutol; INH: isoniazid; PZA: pyrazinamide; RIF: rifampin.
* For HIV-infected patients who are not receiving antiretroviral therapy, the continuation phase should be extended by three months (or 90 doses) for regimen 1 (above) and for at least three months for regimen 2.[1]
¶ When DOT is used, drugs may be given five days/week, and the necessary number of doses adjusted accordingly. Although there are no studies that compare five with seven daily doses, extensive experience indicated this would be an effective practice.
Δ To help evaluate treatment effectiveness, sputum smears and mycobacterial cultures should be obtained at least monthly until at least two sequential cultures are negative and the patient is responding clinically to antituberculous therapy. Patients treated with regimen 1 with positive cultures at completion of two months of therapy should receive a seven-month (31-week; 217 doses [daily]) continuation phase; those receiving regimen 2 without PZA should probably have their continuation phase extended by three months as well (one year total). Patients with a positive sputum culture after three months of therapy should be evaluated for possible treatment failure.[1]
◊ Five-day-a-week administration is always given by DOT.Data from:
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