Revascularization in patients with inducible ischemia after thrombolysis improves outcome

The DANAMI study randomly assigned 1008 postinfarction patients with spontaneous or exercise-induced ischemia after thrombolytic therapy for acute myocardial infarction to conservative therapy or invasive therapy with revascularization, if appropriate, based on anatomy. The invasive strategy significantly reduced the incidence of reinfarction, death, or admission for unstable angina (44 versus 32 percent at four years [upper panel]) but did not affect total mortality (lower panel).