Point mutations in the heme pocket resulting in unstable hemoglobins
Point mutations in the heme pocket resulting in unstable hemoglobins
Schematic representation of the heme pocket, showing the resulting amino acid changes that produce several of the unstable hemoglobins. Valine E4 is at the corner of the pocket; its side chain does not make contact with the heme but does affect the placement of adjacent amino acid side chains.
Blue circle in the center of the molecule with "Fe": iron
