Version June 2024
| Response category | Definition |
| Complete remission | No clinical evidence of disease or disease-related symptoms. |
| A post-treatment residual mass of any size is permitted as long as it is PET negative. | |
| Spleen and liver must be non-palpable and without nodules. | |
| If a pre-treatment bone marrow biopsy was positive, an adequate bone marrow biopsy (with a core size of at least 20 mm) from the same site must be cleared of infiltrate; if this is indeterminate by morphology, immunohistochemistry should be negative. | |
| Partial remission | A decrease by at least 50 percent in the sum of the products of the largest perpendicular diameters (SPD) of up to six of the largest measurable lesions. |
| The post-treatment PET should be positive in at least one previously involved site. | |
| There should be no increase in the size of other nodes, liver, or spleen and no new areas of disease. | |
| Splenic or hepatic nodules must decrease by at least 50 percent in the SPD (or in the greatest transverse diameter for single nodules). | |
| Bone marrow biopsy results are not useful in determining PR. However, if the patient otherwise fits the CR criteria but has a positive bone marrow biopsy, the patient is labeled as having a PR. | |
| Stable disease | Failure to attain a CR or PR with no evidence of progressive disease. The post-treatment PET should be positive at prior sites of disease and no new sites should be present on PET or CT. |
| Progressive disease or relapse after CR | Any new lesion or an increase from nadir by at least 50 percent of previously involved sites. |
| Development of a new lesion is defined by the appearance of any new lesion more than 1.5 cm in long axis. If the long axis diameter is from 1.1 to 1.5 cm, the lesion should only be considered abnormal if its short axis is more than 1.0 cm. | |
| Progressive disease is also defined as an increase of at least 50 percent in the longest diameter of a previously identified node more than 1 cm in short axis or in the SPD of more than one node. | |
| Lesions should be PET positive unless they are below a detectable size (ie, <1.5 cm in long axis by CT). |
آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
