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Histologic grading of the effect of preoperative chemotherapy on primary osteosarcoma

Histologic grading of the effect of preoperative chemotherapy on primary osteosarcoma
Grade Effect
I Little or no effect identified
II Areas of acellular tumor osteoid, necrotic, or fibrotic material attributable to the effect of chemotherapy, with other areas of histologically viable tumor
III Predominant areas of acellular tumor osteoid, necrotic, or fibrotic material attributable to the effect of chemotherapy, with only scattered foci of histologically viable tumor cells identified
IV No histologic evidence of viable tumor identified within the entire specimen
Histol_grading_post_preop_c.htm
Reproduced with permission from: Rosen G, et al. Primary osteogenic sarcoma: eight year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol 1983; 106 (suppl):55. Copyright © 1983 Springer-Verlag.
Graphic 58829 Version 2.0

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