Possible interaction between beta blockers and amiodarone after acute MI

An intention to treat analysis of the two-year total cardiac mortality in 1486 patients with a recent acute myocardial infarction (MI) and a left ventricular ejection fraction below 40 percent in the EMIAT trial. Those receiving a beta blocker with amiodarone had a trend toward a better outcome compared to patients receiving amiodarone alone (P = 0.06). No effect of concomitant therapy with digoxin or ACE inhibitors was noted.