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Cairo-Bishop definition of laboratory tumor lysis syndrome

Cairo-Bishop definition of laboratory tumor lysis syndrome
Element Value Change from baseline
Uric acid ≥476 micromol/L (8 mg/dL) 25% increase
Potassium ≥6.0 mmol/L (or 6 mEq/L) 25% increase
Phosphorus

≥2.1 mmol/L (6.5 mg/dL) for children or

≥1.45 mmol/L (4.5 mg/dL) for adults

25% increase
Calcium ≤1.75 mmol/L (7 mg/dL) 25% decrease
NOTE: Two or more laboratory changes within three days before or seven days after cytotoxic therapy.
Reproduced with permission from: Coiffier B, Altman A, Pui CH, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 2008; 26:2767. Copyright ©2008 American Society of Clinical Oncology. All rights reserved.
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