Cairo-Bishop definition of laboratory tumor lysis syndrome
|Element ||Value ||Change from baseline |
|Uric acid ||≥476 micromol/L (8 mg/dL) ||25% increase |
|Potassium ||≥6.0 mmol/L (or 6 mEq/L) ||25% increase |
|Phosphorus || |
≥2.1 mmol/L (6.5 mg/dL) for children or
≥1.45 mmol/L (4.5 mg/dL) for adults
|25% increase |
|Calcium ||≤1.75 mmol/L (7 mg/dL) ||25% decrease |
NOTE: Two or more laboratory changes within three days before or seven days after cytotoxic therapy.
Reproduced with permission from: Coiffier B, Altman A, Pui CH, et al. Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. J Clin Oncol 2008; 26:2767. Copyright ©2008 American Society of Clinical Oncology. All rights reserved.
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