Dose-response of daily subcutaneous injections of a recombinant form of TPO, PEG-rHuMGDF, for 28 days on the peripheral platelet count in baboons. The daily doses were 0.05 (squares), 0.10 (triangles), 0.50 (closed circle), and 2.50 (open circle) mcg/kg.
PEG-rHuMGDF: PEG-recombinant human megakaryocyte growth and development factor.
Adapted from: Harker LA, Marzec UM, Hunt P, et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996; 88:511.
