Lethal pulmonary hypoplasia due to skeletal dysplasia

(A and B) Lethal pulmonary hypoplasia, subtype unknown, diagnosed at 13 weeks of gestation on the basis of a small chest circumference. The chest circumference (circle in A) is significantly smaller than the abdominal circumference (circle in B). Pathological diagnosis was dyssegmental dysplasia.
(A) Cross-section of the thorax.
(B) Cross-section of the abdomen.
(C and D) Lethal pulmonary hypoplasia on the basis of a small thorax.
(C) Thanatophoric dysplasia at 23 weeks. Sagittal ultrasound demonstrates the markedly narrow anteroposterior diameter of the thorax (between arrows). The heart fills almost the entire thorax. The abdomen appears relatively protuberant compared with the constricted thorax.
(D) Osteogenesis imperfecta type 2 at 21 weeks. Coronal ultrasound demonstrates the bell-shaped contour of the thorax and narrow transverse diameter relative to the abdomen.