Hyperfractionated radiation therapy for diffuse intrinsic pontine gliomas

Protocol [references]	Number of patients	Dose per fx/total dose	TTP (mos)	MST (mos)	Survival (percent)
Protocol [references]	Number of patients	Dose per fx/total dose	TTP (mos)	MST (mos)	1 year	2 years	3 years
POG* ^{[1, 2, 3]}	38	1.1 Gy/66 Gy	6.5	11	48	6	3
	57	1.17 Gy/70.2 Gy	6	10	40	23	21
	39	1.26 Gy/75.6 Gy	7	10	39	6	6
CHOP/NYU ^[4]	16	1.2 Gy/64.8 Gy	7	11	48
CHOP/NYU ^[4]	35	1 Gy/72 Gy	8			28
CCG ^{[5, 6, 7]}	53	1 Gy/72 Gy	5.5	9	38	14	8
CCG ^{[5, 6, 7]}	66	1 Gy/78 Gy	8	9.5	35	22	11
UCSF ^{[8, 9]}	20	1 Gy/72Gy	9	12
UCSF ^{[8, 9]}	39	1 Gy/78 Gy	8.4	10.8

TTP: time to progression; MST: median survival time; POG: Pediatric Oncology Group; CHOP: Children's Hospital of Philadelphia; NYU: New York University; CCG: Children's Cancer Group; UCSF: University of California, San Francisco.

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Hyperfractionated radiation therapy for diffuse intrinsic pontine gliomas