Version May 2024
| Antiseizure medication | Systemic side effects | Neurologic side effects |
| Brivaracetam* | Nausea, vomiting, constipation, fatigue | Headache, somnolence, dizziness, ataxia, abnormal coordination, nystagmus |
| Cannabidiol | Anemia, decreased appetite, diarrhea, infection, dose-related elevations of liver transaminases (ALT and/or AST), rash, fatigue | CNS depression (eg, drowsiness, lethargy, sedation), malaise, insomnia, sleep disturbance |
| Carbamazepine | Nausea, vomiting, diarrhea, hyponatremia, rash, pruritus | Drowsiness, dizziness, blurred or double vision, lethargy, headache |
| Cenobamate | Fatigue | Somnolence, dizziness, headache, diplopia |
| Clobazam | Increased salivation, nausea, vomiting, constipation | Somnolence, aggression, irritability, ataxia, insomnia |
| Eslicarbazepine | Nausea, vomiting, diarrhea, fatigue, hyponatremia, rash | Dizziness, drowsiness, headache, diplopia, vertigo, ataxia, attention disturbance, blurred vision, tremor (NOTE: Dizziness, diplopia, and ataxia reported more frequently in combination with carbamazepine) |
| Ethosuximide | Nausea, vomiting | Sleep disturbance, drowsiness, hyperactivity |
| Felbamate | Nausea, vomiting, anorexia, weight loss | Insomnia, dizziness, headache, ataxia |
| Gabapentin | Infrequent | Somnolence, dizziness, ataxia |
| Lacosamide | Nausea, vomiting, fatigue | Ataxia, dizziness, headache, diplopia |
| Lamotrigine | Rash, nausea | Dizziness, tremor, diplopia |
| Levetiracetam | Fatigue, infection | Somnolence, dizziness, agitation, anxiety, irritability, depression |
| Oxcarbazepine | Nausea, rash, hyponatremia | Sedation, headache, dizziness, vertigo, ataxia, diplopia |
| Perampanel | Weight gain, fatigue, nausea | Dizziness, somnolence, irritability, gait disturbance, falls, aggression, mood alteration |
| Phenobarbital | Nausea, rash | Alteration of sleep cycles, sedation, lethargy, behavioral changes, hyperactivity, ataxia, tolerance, dependence |
| Phenytoin | Gingival hypertrophy, rash | Confusion, slurred speech, double vision, ataxia |
| Pregabalin | Weight gain, peripheral edema, dry mouth | Dizziness, somnolence, ataxia, tremor |
| Primidone | Nausea, rash | Alteration of sleep cycles, sedation, lethargy, behavioral changes, hyperactivity, ataxia, tolerance, dependence |
| Rufinamide | Nausea, vomiting, fatigue | Dizziness, somnolence, headache |
| Stiripentol | Nausea, decreased appetite, weight loss | Somnolence, agitation, ataxia, hypotonia, tremor, dysarthria, insomnia |
| Tiagabine | Abdominal pain, nausea, lack of energy | Dizziness, somnolence, nervousness, tremor, difficulty concentrating |
| Topiramate | Weight loss, paresthesia, fatigue | Nervousness, difficulty concentrating, confusion, depression, anorexia, language problems, anxiety, mood problems, tremor |
| Valproate | Weight gain, nausea, vomiting, hair loss, easy bruising | Tremor, dizziness |
| Vigabatrin | Vision loss, fatigue | Drowsiness, dizziness |
| Zonisamide | Nausea, anorexia | Somnolence, dizziness, ataxia, confusion, difficulty concentrating, depression |
ALT: alanine aminotransferase; AST: aspartate aminotransferase; CNS: central nervous system.
* Based upon limited experience from preapproval clinical trials.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
