Amsterdam II criteria for Lynch syndrome

There should be at least three relatives with any Lynch syndrome-associated cancer (colorectal cancer, cancer of the endometrium, small bowel, ureter, or renal pelvis)

One should be a first-degree relative of the other two

At least two successive generations should be affected

At least one should be diagnosed before age 50

Familial adenomatous polyposis should be excluded in the colorectal cancer case(s), if any

Tumors should be verified by pathological examination

Adapted from Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 1999; 116:1453.

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Amsterdam II criteria for Lynch syndrome