Morphologic features associated with malignancy on needle biopsy of the prostate

Morphologic feature	Malignant lesions, percent (n = 100)	Benign lesions, percent (n = 150)
Prominent nucleoli	94	25
Marginated nucleoli	88	7
Multiple nucleoli	64	0
Blue-tinged mucinous secretions	52	0
Intraluminal crystalloids	41	1
Intraluminal amorphous eosinophilic material	87	2
Collagenous micronodules	2	0
Glomerulations	15	0
Perineural invasion	22	0
Retraction clefting	39	7
Invasion of fat	0.7	0

Morphology_prost_CA_needle.htm

Modified from Varma M, Lee MW, Tamboli P, et al. Morphologic criteria for the diagnosis of prostatic adenocarcinoma in needle biopsy specimens. A study of 250 consecutive cases in a routine surgical pathology practice. Arch Pathol Lab Med 2002; 126:554.

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Morphologic features associated with malignancy on needle biopsy of the prostate