Version May 2024
| Agent | Regimen | Maximum daily dose |
| Intravenous therapy | ||
| Ampicillin* | Penicillin susceptible (MIC ≤2 mcg/mL): 150 to 200 mg/kg per day divided in 4 doses | 6 g/day |
| Penicillin resistant or intermediate (MIC ≥4 mcg/mL): 300 to 400 mg/kg per day divided in 4 doses | 12 g/day | |
| Cefotaxime¶ | 150 mg/kg per day divided in 3 doses | 6 g/day |
| Ceftaroline | 2 through 23 months: 24 mg/kg per day divided in 3 doses | 1.2 g/day |
2 through 17 years:
| ||
| ≥18 years: 1.2 g per day divided in 2 doses | ||
| Ceftriaxone¶ | Penicillin susceptible (MIC ≤2 mcg/mL): 50 to 100 mg/kg per day divided in 1 or 2 doses | 2 g/day |
| Penicillin resistant or intermediate (MIC ≥4 mcg/mL): 100 mg/kg per day divided in 1 or 2 doses | 4 g/day | |
| ClindamycinΔ (if susceptible) | 40 mg/kg per day divided in 3 or 4 doses | 2.7 g/day |
| Penicillin G* | 200,000 to 250,000 units/kg per day divided in 4 or 6 doses | 24 million units/day |
| LevofloxacinΔ (if susceptible) | 6 months to 5 years: 16 to 20 mg/kg per day divided in 2 doses | 750 mg/day |
| 5 to 16 years: 8 to 10 mg/kg once daily | ||
| Linezolid | <12 years: 30 mg/kg per day divided in 3 doses | 1.8 g/day |
| ≥12 years: 20 mg/kg per day divided in 2 doses | 1.2 g/day | |
| VancomycinΔ | 40 to 60 mg/kg per day divided in 3 or 4 doses◊ | 4 g/day◊ |
| Oral therapy (for mild infection or completion of a course of therapy initiated intravenously) | ||
| Amoxicillin* | 90 mg/kg per day divided in 2 doses | 4 g/day |
| 45 mg/kg per day divided in 3 doses | 4 g/day | |
| Cefpodoxime | 10 mg/kg per day divided in 2 doses | 400 mg/day |
| Cefprozil | 15 to 30 mg/kg per day divided in 2 doses | 1 g/day |
| Cefuroxime | 20 to 30 mg/kg per day divided in 2 doses | 1 g/day |
| ClindamycinΔ (if susceptible) | 30 to 40 mg/kg per day divided in 3 doses | 1.8 g/day |
| Levofloxacin¶ (if susceptible) | 6 months to 5 years: 16 to 20 mg/kg per day divided in 2 doses | 750 mg/day |
| 5 to 16 years: 8 to 10 mg/kg once daily | ||
| Linezolid¶ | <12 years: 30 mg/kg per day divided in 3 doses | 1.8 g/day |
| ≥12 years: 20 mg/kg per day divided in 2 doses | 1.2 g/day | |
* Preferred agents for penicillin susceptible S. pneumoniae.
¶ Preferred agents for penicillin nonsusceptible S. pneumoniae.
Δ Alternative agents for children with severe allergic reactions to beta-lactam antibiotics.
◊ 60 mg/kg per day is recommended for children with serious infections (eg, toxic-appearing or have evidence of complications such as empyema). Adjustment of dose and frequency may be necessary based upon serum concentration monitoring.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
