Radiologic features and differential diagnosis of idiopathic interstitial pneumonias

Clinical diagnosis	Histologic pattern	Chest radiographic features	Typical distribution	Typical CT findings	Differential diagnosis
IPF/CFA	UIP	Basal-predominant reticular abnormality with volume loss	Peripheral, subpleural, basal	Reticular opacities, traction bronchiectasis/bronchiolectasis, architectural distortion, honeycombing. May have mild ground glass	Asbestosis, collagen vascular disease, hypersensitivity pneumonitis, sarcoidosis
NSIP	NSIP	Ground glass and reticular opacity	Peripheral, basal, symmetric	Ground glass attenuation, irregular lines, consolidation	UIP, DIP, COP, hypersensitivity pneumonitis
COP	OP	Patchy bilateral consolidation	Subpleural/peribronchial	Patchy consolidation and/or nodules, perilobular pattern, reverse halo sign	Infection, vasculitis, sarcoidosis, mucinous adenocarcinoma, lymphoma, eosinophilic pneumonia, NSIP
AIP	DAD	Progressive diffuse ground glass density/consolidation	Diffuse	Consolidation and ground glass opacity, often with lobular sparing. Traction bronchiectasis later	Hydrostatic edema, pneumonia, acute eosinophilic pneumonia
DIP	DIP	Ground glass opacity	Lower zone, peripheral predominance in most	Ground glass attenuation, reticular opacities	RB-ILD, hypersensitivity pneumonitis, sarcoidosis, PCP
RB-ILD	RB	Bronchial wall thickening; ground glass opacity	Diffuse	Bronchial wall thickening, centrilobular nodules, patchy ground glass opacity	DIP, NSIP, Hypersensitivity pneumonitis
LIP	LIP	Reticular opacities, nodules	Diffuse	Centrilobular nodules, ground glass attenuation, septal and bronchovascular thickening, thin-walled cysts	Sarcoidosis, lymphangitic carcinoma, Langerhans' cell histiocytosis
IPPFE	IPPFE	Bilateral apical pleural thickening and adjacent fibrosis	Upper lung zone, peripheral	Bilateral apical irregular pleural thickening with subjacent consolidation, reticular opacities and traction bronchiectasis	Radiation fibrosis, pneumoconiosis, sarcoidosis, hypersensitivity pneumonitis, collagen vascular disease, familial pulmonary fibrosis, drug-induced PPFE

AIP: acute interstitial pneumonia; CFA: cryptogenic fibrosing alveolitis; COP: cryptogenic organizing pneumonia; DAD: diffuse alveolar damage; DIP: desquamative interstitial pneumonia; IPF: idiopathic pulmonary fibrosis; IPPFE: idiopathic pleuroparenchymal fibroelastosis; LIP: lymphoid interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; OP: organizing pneumonia; PCP: Pneumocystis pneumonia; RB-ILD: respiratory bronchiolitis-associated interstitial lung disease; UIP: usual interstitial pneumonia.

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خرید پکیج

Radiologic features and differential diagnosis of idiopathic interstitial pneumonias