Structure of the VWF gene including common VWD-associated mutations and domain structure of the protein showing binding sites

Structure of the VWF gene including common VWD-associated mutations and domain structure of the protein showing binding sites

Types 1 and 3 VWD mutations are not shown in the figure because they are distributed widely throughout the VWF sequence. Refer to UpToDate for additional information about D domain assemblies.

VWF: von Willebrand factor; VWD: von Willebrand disease; TIL: trypsin inhibitor-like domain; GPIb: glycoprotein Ib.

Graphic 60152 Version 9.0

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Structure of the VWF gene including common VWD-associated mutations and domain structure of the protein showing binding sites