Cullen's definition of idiopathic environmental intolerance

1. A disorder acquired after a documented environmental exposure, insult, or illness.

2. Symptoms involving more than one organ system.

3. Symptoms that recur and abate in response to predictable stimuli.

4. Symptoms elicited by exposures to chemical of diverse structural class and toxicologic modes of action.

5. Symptoms that are elicited by exposures that are demonstrable.

6. Exposures that elicit symptoms are generally lower than 1 percent of established threshold limit values.

7. No single widely available test of organ system function can explain symptoms.

Cullens_definition_IEI.htm

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