Risk factors for outcome in adults with acute myeloid leukemia

Favorable factors	Unfavorable factors
Age <50	Age >60
Karnofsky score >60 percent	Karnofsky score <60 percent
MDR 1-negative phenotype	MDR 1-positive phenotype
No antecedent hematologic disorder or prior chemo/radiotherapy	Therapy-related AML, prior myelodysplastic syndrome, myeloproliferative or other hematologic disorder
t(8;21), inv(16)/t(16;16), t(15;17)	Complex karyotypic abnormalities, -5, -7, 3q26 aberrations, t(6;9), 11q23 aberrations except for t(9;11), "monosomal karyotype"
NPM1 mutation, CEBPA mutation	FLT3/ITD mutation, MLL partial tandem duplication, BAALC overexpression, mutations in IDH1 and/or IDH2

AML: acute myeloid leukemia.

Graphic 60295 Version 6.0