Version May 2024
| Regimen | Pediatric dose | Adult dose |
| Two-drug regimens | ||
| Ceftriaxone OR | 50 to 100 mg/kg per day once daily or in two divided doses Maximum daily dose 2 g | 2 g every 24 hours |
| Cefotaxime | 150 to 200 mg/kg per day in four divided doses Maximum daily dose 10 g | 2 g every 4 to 8 hours |
| PLUS | ||
| Vancomycin* OR | 40 to 60 mg/kg per day in three to four divided doses Maximum daily dose 2 g | Loading dose:¶ 20 to 35 mg/kg Initial maintenance dose and interval determined by nomogram;Δ typically 15 to 20 mg/kg every 8 to 12 hours for most patients with normal renal function Subsequent dose and interval adjustments based on AUC-guided (preferred) or trough-guided serum concentration monitoring◊ |
| Clindamycin OR | 30 to 40 mg/kg per day in three divided doses Maximum daily dose 2.7 g | 600 to 900 mg every 8 hours |
| Oxacillin§ OR | 150 to 200 mg/kg per day in four divided doses Maximum daily dose 12 g | 1 to 2 g every 4 to 6 hours |
| Nafcillin§ OR | 150 to 200 mg/kg per day in four divided doses Maximum daily dose 12 g | 2 g every 4 hours |
| Cefazolin§ | 75 to 100 mg/kg per day in three divided doses Maximum daily dose 6 g | 1 to 2 g every 6 hours |
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