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2010 ENETS/WHO nomenclature and classification for neuroendocrine neoplasms arising in the gastrointestinal (GI) tract

2010 ENETS/WHO nomenclature and classification for neuroendocrine neoplasms arising in the gastrointestinal (GI) tract
Differentiation Grade Mitotic count* Ki-67 index Traditional ENETS, WHO
Well differentiated Low grade (G1) <2 per 10 HPF <3% Carcinoid, islet cell, pancreatic (neuro)endocrine tumor Neuroendocrine tumor, G1
Intermediate grade (G2) 2 to 20 per 10 HPF 3 to 20% Carcinoid, atypical carcinoidΔ, islet cell, pancreatic (neuro)endocrine tumor Neuroendocrine tumor, G2
Poorly differentiated High grade (G3) >20 per 10 HPF >20% Small cell carcinoma Neuroendocrine carcinoma, G3, small cell
Large cell neuroendocrine carcinoma Neuroendocrine carcinoma, G3, large cell
ENETS: European Neuroendocrine Tumor Society; WHO: World Health Organization; HPF: high-power fields.
* Counted in 10 HPF; 10 HPF = 2 mm2, at least 40 fields (at 400x magnification) evaluated in areas of highest mitotic density. Cut-offs per American Joint Commission on Cancer Staging Manual, 8th edition.
¶ Ki-67 index as assessed by MIB1 antibody staining: percent positive after count of 2000 cells in area of highest nuclear labeling. Cut-offs per American Joint Commission on Cancer Staging Manual, 8th edition.
Δ The term "atypical carcinoid" only applies to intermediate-grade neuroendocrine tumors of the lung.
Graphic 60365 Version 15.0

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