First-generation agents | |
Generic name | Brand name* |
Chlorpromazine | Thorazine |
Droperidol | Inapsine |
Flupentixol¶Δ | Fluanxol |
Fluphenazine¶ | Prolixin |
Haloperidol¶ | Haldol |
Levomepromazine (methotrimeprazine)Δ | Methoprazine, Nozinan |
Loxapine | Adasuve, Loxitane |
PericyazineΔ | Neuleptil |
Perphenazine | Trilafon |
Pimozide | Orap |
Thioridazine | Mellaril |
Thiothixene | Navane |
Trifluoperazine | Stelazine |
Zuclopenthixol¶Δ | Clopixol |
Second-generation agents | |
Generic name | Brand name◊ |
AmisulprideΔ | Solian |
Aripiprazole¶ | Abilify, Abilify Maintena, Abilify Asimtufil, Aristada |
Asenapine | Saphris |
Brexpiprazole | Rexulti |
Cariprazine | Vraylar |
Clozapine | Clozaril, Fazaclo, Versacloz |
Iloperidone | Fanapt |
Lumateperone | Caplyta |
Lurasidone | Latuda |
Olanzapine¶ | Zyprexa, Zyprexa Relprevv, Zyprexa Zydis |
Paliperidone¶ | Invega, Invega Sustenna, Invega Hafyera, Invega Trinza |
Pimavanserin | Nuplazid |
Quetiapine | Seroquel, Seroquel XR |
Risperidone¶ | Perseris, Risperdal, Risperdal Consta, Rykindo, Risvan, Uzedy |
Xanomeline-trospium§ | Cobenfy |
Ziprasidone | Geodon, Zeldox |
* Most first-generation antipsychotics are available only as generic versions in United States (US).
¶ Also available as a long-acting depot injection.
Δ Available in Canada and many other countries; but not US. Amisulpride formulation available in the US is a short-acting IV used for postoperative nausea/vomiting. It is widely available in other countries as an oral antipsychotic (Solian).
◊ Brand names of second-generation agents available in US, Canada, and many other countries.
§ Novel (first-in-class) dual M1 and M4 muscarinic receptor agonist; unlike other antipsychotic agents, xanomeline-trospium does not blockade brain D2 dopamine receptors.