Version July 2025
| First-generation agents | |
| Generic name | Brand name* |
| Chlorpromazine | Thorazine |
| Droperidol | Inapsine |
| Flupentixol¶Δ | Fluanxol |
| Fluphenazine¶ | Prolixin |
| Haloperidol¶ | Haldol |
| Levomepromazine (methotrimeprazine)Δ | Methoprazine, Nozinan |
| Loxapine | Adasuve, Loxitane |
| PericyazineΔ | Neuleptil |
| Perphenazine | Trilafon |
| Pimozide | Orap |
| Thioridazine | Mellaril |
| Thiothixene | Navane |
| Trifluoperazine | Stelazine |
| Zuclopenthixol¶Δ | Clopixol |
| Second-generation agents | |
| Generic name | Brand name◊ |
| AmisulprideΔ | Solian |
| Aripiprazole¶ | Abilify, Abilify Maintena, Abilify Asimtufil, Aristada |
| Asenapine | Saphris |
| Brexpiprazole | Rexulti |
| Cariprazine | Vraylar |
| Clozapine | Clozaril, Fazaclo, Versacloz |
| Iloperidone | Fanapt |
| Lumateperone | Caplyta |
| Lurasidone | Latuda |
| Olanzapine¶ | Zyprexa, Zyprexa Relprevv, Zyprexa Zydis |
| Paliperidone¶ | Invega, Invega Sustenna, Invega Hafyera, Invega Trinza |
| Pimavanserin | Nuplazid |
| Quetiapine | Seroquel, Seroquel XR |
| Risperidone¶ | Perseris, Risperdal, Risperdal Consta, Rykindo, Risvan, Uzedy |
| Xanomeline-trospium§ | Cobenfy |
| Ziprasidone | Geodon, Zeldox |
* Most first-generation antipsychotics are available only as generic versions in United States (US).
¶ Also available as a long-acting depot injection.
Δ Available in Canada and many other countries; but not US. Amisulpride formulation available in the US is a short-acting IV used for postoperative nausea/vomiting. It is widely available in other countries as an oral antipsychotic (Solian).
◊ Brand names of second-generation agents available in US, Canada, and many other countries.
§ Novel (first-in-class) dual M1 and M4 muscarinic receptor agonist; unlike other antipsychotic agents, xanomeline-trospium does not blockade brain D2 dopamine receptors.
