Version May 2024
| Preferred treatment | Comments | |
| Severe pulmonary disease | Amphotericin B for 1 to 2 weeks, followed by itraconazole for 6 to 12 months*. | Treat children with severe disease for 12 months. |
| Mild to moderate pulmonary disease | Itraconazole for 6 to 12 months. | |
| Severe disseminated disease | Amphotericin B for 1 to 2 weeks followed by itraconazole for 12 months. | |
| Mild to moderate disseminated disease | Itraconazole for 6 to 12 months. | Treat osteoarticular disease for 12 months. |
| CNS disease | Amphotericin B for 4 to 6 weeks is preferred, followed by voriconazole for at least 12 months. | Alternative step-down therapy for CNS disease can be itraconazole 200 mg 2 to 3 times per day or fluconazole 800 mg per day. Immunocompromised patients may require extended therapy. |
| Immunocompromised patients | Amphotericin B for 1 to 2 weeks, followed by itraconazole for 12 months. | Life-long suppressive treatment may be required if immunosuppression cannot be reversed. |
| Pregnant patients | Amphotericin B throughout pregnancy. | Azoles should not be used during pregnancy. |
CNS: central nervous system.
* The entire course of therapy can be given with amphotericin B; however, most clinicians prefer to use step-down itraconazole therapy after the patient's condition improves.آیا می خواهید مدیلیب را به صفحه اصلی خود اضافه کنید؟
