Evidence-based classification system for drug-induced acute pancreatitis (revised)

Class 1. High-quality of evidence for causation of acute pancreatitis: Randomized controlled clinical trials

Class 2. Moderate-quality of evidence for causation of acute pancreatitis: Case-control studies and/or pharmacoepidemiology studies

Class 3. Low-quality evidence for causation of acute pancreatitis: High-quality case reports

Class 3a: Case reports showing "rechallenge and consistent latency"

Class 3b: Case report showing rechallenge only

Class 3c: Case report showing consistent latency only

Class 4. Very low-quality evidence: High-quality case reports but no rechallenge nor consistent latency

From: Saini J, Marino D, Badalov N, et al. Drug-induced acute pancreatitis: An evidence-based classification (revised). Clin Transl Gastroenterol 2023; 14:e00621. Copyright © 2023 The Authors. https://journals.lww.com/ctg/fulltext/2023/08000/drug_induced_acute_pancreatitis__an_evidence_based.8.aspx (Accessed November 6, 2024). Reproduced under the terms of the Creative Commons Attribution License 4.0.

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