Classification system of drug-induced acute pancreatitis

Class Ia drugs

At least 1 case report with positive rechallenge, excluding all other causes, such as alcohol, hypertriglyceridemia, gallstones, and other drugs

Class Ib drugs

At least 1 case report with positive rechallenge; however, other causes, such as alcohol, hypertriglyceridemia, gallstones, and other drugs were not ruled out

Class II drugs

At least 4 cases in the literature

Consistent latency (≥75 percent of cases)

Class III drugs

At least 2 cases in the literature

No consistent latency among cases

No rechallenge

Class IV drugs

Drugs not fitting into the earlier-described classes, single case report published in medical literature, without rechallenge

Classification_drug_induced.htm

Reproduced with permission from: Badalov N, Baradarian R, Kadirawel I, et al. Drug-Induced Acute Pancreatitis: An Evidence-Based Review. Clin Gastroenterol Hepatol 2007; 5:648. Copyright © 2007 Elsevier.

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Classification system of drug-induced acute pancreatitis