Cause | Relative gastrin level |
Decreased acid production |
Chronic atrophic gastritis - type A |
| ++++ |
- Other immunologic associations (eg, vitiligo, rheumatoid arthritis, Sjögren's disease, diabetes mellitus)
| + |
Chronic atrophic gastritis - type B (eg, H. pylori-induced) | ++ |
Renal insufficiency | + |
Gastrin cell hyperplasia | + or ++ |
Antisecretory therapy |
| + |
| ++ |
Truncal vagotomy | + |
Increased acid production |
Gastrinoma | ++++ |
Other tumors (ovarian cancer, pheochromocytoma) | + or ++ |
Massive small bowel resection | + or ++ |
Retained gastric antrum | ++ |
Antral G cell hyperplasia | ++ |
Gastric outlet obstruction | + |