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HBV precore/core open reading frame

HBV precore/core open reading frame
Schematic representation of the HBV precore/core open reading frame (ORF), RNA transcripts and translational products in wild type and precore mutant viruses. The precore region consists of 87 nucleotides coding for 29 amino acids. In the wild type virus, the precore mRNA is processed at the N and C terminal ends to HBeAg, a secretory protein (upper panel). In the mutant virus, a G-A mutation at nucleotide 1896 in the precore region results in a premature stop codon at codon 28 preventing the production of HBeAg (lower panel). The pregenomic RNA is translated to the core protein (HBcAg); it is also translated to the polymerase protein and reverse transcribed into HBV DNA.
Graphic 61295 Version 1.0

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