Potential sources for cytokines implicated in scleroderma pathogenesis

Cell type	Major cytokine products
Endothelial cells
Activated or damaged	IL-1, IL-6, IL-8, IGF-1, PDGF, TGF-beta, ET-1
Immune or inflammatory cells
Monocyte/macrophage	IL-1, TNF
Lymphocytes	IL-2, -4, -6, -8
Mast cells, neutrophils, eosinophils	bFGF, proteases
Fibroblasts
Scleroderma fibroblasts	TNF, IL-1, IL-6, TGF-beta, IGF-1, DGF

Cytokine_sources_in_sclerod.htm

Graphic 62238 Version 1.0

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