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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Platinum-based combination regimens for advanced NSCLC

Platinum-based combination regimens for advanced NSCLC
Regimen Dose and schedule Frequency Reference
Carboplatin/Paclitaxel

Paclitaxel 225 mg/m2 over 3 hours

Carboplatin AUC 6 mg/mL/min		 Every 3 weeks J Clin Oncol 2005; 23:190.

Paclitaxel 100 mg/m2

Carboplatin AUC 2 mg/mL/min		 Weekly Clin Lung Cancer 2006; 7:338.
Carboplatin/Docetaxel

Carboplatin AUC 6 mg/mL/min

Docetaxel 75 mg/m2		 Every 3 weeks J Clin Oncol 2003; 21:3016.
Carboplatin/Gemcitabine

Carboplatin AUC 5 mg/mL/min

Gemcitabine 1200 mg/m2 days 1, 8		 Every 3 weeks Lung Cancer 2003; 41:321.
Carboplatin/Paclitaxel/Bevacizumab

Carboplatin AUC 6 mg/mL/min day 1

Paclitaxel 200 mg/m2 day 1

Bevacizumab 15 mg/kg day 1		 Every 3 weeks* N Engl J Med 2006; 355:2542.
Carboplatin/Pemetrexed

Carboplatin AUC 5 mg/mL/min day 1

Pemetrexed 500 mg/m2 day 1		 Every 3 weeks J Clin Oncol 2007; 25:388s.
Carboplatin/Vinorelbine

Carboplatin AUC 4 day 1

Vinorelbine 25 mg/m2 day 1, 8		 Every 3 weeks Br J Cancer 2007; 97:283.
Cisplatin/Etoposide

Cisplatin 100 mg/m2

Etoposide 100 mg/m2 days 1, 2, 3		 Every 3 weeks Ann Oncol 1997; 8:525.
Cisplatin/Vinorelbine

Cisplatin 100 mg/m2 day 1

Vinorelbine 25 mg/m2 days 1, 8, 15, 22		 Every 4 weeks J Clin Oncol 1998; 16:2459.
Cisplatin/Paclitaxel

Cisplatin 75 mg/m2

Paclitaxel 135 mg/m2		 Every 3 weeks J Clin Oncol 2000; 18:623.
Cisplatin/Docetaxel

Cisplatin 75 mg/m2

Docetaxel 75 mg/m2		 Every 3 weeks J Clin Oncol 2003; 21:3016.
Cisplatin/Gemcitabine

Cisplatin 100 mg/m2 day 1

Gemcitabine 1000 mg/m2 days 1, 8, 15		 Every 4 weeks J Clin Oncol 2000; 18:122.
Cisplatin/Pemetrexed

Cisplatin 75 mg/m2 day 1

Pemetrexed 500 mg/m2 day 1		 Every 3 weeks Scagliotti G. J Clin Oncol 2008.
Cisplatin/Irinotecan

Cisplatin 80 mg/m2 day 1

Irinotecan 60 mg/m2 days 1, 8, 15		 Every 4 weeks Proc Am Soc Clin Oncol 2004; 22:618s.
Cisplatin/Gemcitabine/Necitumumab

Necitumumab 800 mg days 1 and 8

Gemcitabine 1250 mg/m2 days 1 and 8

Cisplatin 75 mg/m2 day 1		 Every 3 weeks Lancet Oncol 2015; 16:763.
These are representative doses and schedules, which have varied in different trials.
AUC: area under the concentration x time curve; NSCLC: non-small cell lung cancer.
* Bevacizumab continued every 3 weeks after completion of six cycles.
Graphic 62287 Version 3.0

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